Solid-form development

Computationally Guided
Solid-Form Risk Assessment

Understand your solid-form risks before committing to further development. DEP combines crystal structure prediction with targeted experimental studies to assess potential alternatives, prioritize what warrants testing, and recommend next steps for your molecule.

Prefer a short video? Learn how the solid-form risk assessment can help.

See how prediction, targeted experiments and DEP’s interpretation connect to support your next decision. Select Play below to begin.

DEP scientific directionDefine the question · Direct the work · Interpret the evidence
01 / COMPUTATIONAL INSIGHT

Explore the possibilities.

Current formSchematic only — not compound data

Assess predicted alternatives and their relative stability within the agreed computational scope.

Output: prioritized questions for testing
02 / TARGETED EXPERIMENTS

Investigate relevant risks.

Use focused studies to investigate selected solid-form questions, including hydrate and solvate behavior where relevant.

Output: experimental and characterization evidence
03 / DEP INTERPRETATION

Decide what comes next.

Connect predicted and observed findings, identify the uncertainties that matter to your decision, and recommend whether further work is warranted.

Output: an actionable development assessment

Computational insight and experimental evidence,
connected through DEP’s scientific direction.

Explore the approach and expertise

See how the work connects.

Read a fictional illustration of the team’s reasoning. It demonstrates an approach, not a client result or a fixed service package.

See an evidence-comparison example →

Relevant expertise

Profiles describe relevant experience. The people involved, their availability, and their roles are confirmed for each engagement.

Sample deliverable

Examples of what you could receive.

Illustrative outline only—not an actual client document or result. Content and depth depend on the agreed scope and available evidence.

Solid-form risk summary

Decision it supports: Which potential alternative forms warrant further investigation?

Evidence overview
Predicted alternatives compared with available experimental findings, with observed evidence and unresolved questions clearly distinguished.
Remaining uncertainty
What the agreed assessment covers, what remains unresolved and why it matters.
Development implications
Recommended follow-up and implications for form selection or further studies.

How you can use it: Helps your team decide what to investigate next based on the combined evidence.

Scope is tailored to the molecule and the decision. Predictions inform experimental evaluation; the assessment does not establish that every possible form has been found.

Before you spend, be sure™.Drug Engine Pharma

Illustrations are schematic. Study design, budget and timing are agreed for each program.

Need to connect solid-form science with IP strategy? Explore our integrated offering →